Curcumin and Liver Health: Is Piperine-Enhanced Curcumin Putting You at Risk?

Exploring the Safety of High-Bioavailability Curcumin Supplements Versus Traditional Turmeric Use

BY BRIAN S.

Curcumin is hailed for its anti-inflammatory benefits, but can piperine-enhanced supplements cause liver toxicity? Discover the science behind turmeric, bioavailability, and hepatotoxicity risk.

Turmeric (Curcuma longa) has been revered in traditional medicine for centuries, especially in systems such as Ayurveda and Jamu. Its main active component, curcumin, is known for potent anti-inflammatory and antioxidant properties. However, the modern supplement industry has isolated curcumin and combined it with piperine (from black pepper) to improve its notoriously low bioavailability. While this may seem like a win for effectiveness, emerging evidence suggests it could come with unintended risks—including hepatotoxicity.

The Hepatotoxicity Issue: Real but Reversible

A number of recent case reports have shown that some individuals develop drug-induced liver injury (DILI) from high-dose curcumin supplementation, especially when taken with piperine. Symptoms often include jaundice, elevated liver enzymes, and fatigue, but fortunately, these effects appear to be reversible upon discontinuation of the supplement.

For example, Lukefahr et al. (2020) reviewed several cases of liver injury linked to curcumin-piperine combinations. These individuals had no prior liver disease and recovered fully after stopping supplementation.

The Role of Piperine in Liver Toxicity

Piperine plays a double-edged role. While it enhances curcumin absorption by up to 2000% (Shoba et al., 1998), it does so by inhibiting key liver enzymes, namely CYP3A4 and UGT (UDP-glucuronosyltransferase). These enzymes are critical for metabolizing curcumin and detoxifying many drugs. By blocking them, piperine can cause curcumin (and possibly other substances) to accumulate in the liver, potentially leading to oxidative stress and toxicity.

This becomes particularly concerning when curcumin is consumed in doses far exceeding traditional dietary intake.

🌿 Whole Turmeric: A Safer, Synergistic Alternative?

Contrast this with whole turmeric powder, which contains not only curcuminoids but also essential oils, polysaccharides, and natural compounds that may buffer and balance curcumin’s effects. Traditional use of turmeric in diets—up to 1 teaspoon three times daily over years—has not been associated with jaundice or liver dysfunction in anecdotal or ethnomedical records.

This underscores a key principle: whole herbs often operate within a safety buffer that isolated compounds do not.

⚖️ A Comparative Look: Whole Turmeric vs. Curcumin Supplement

Feature	Whole Turmeric	Curcumin + Piperine
Bioavailability	Low	Very high
Synergistic compounds	Present	Lacking
Safety record	Long-term, favorable	Limited, concerns exist
Mechanism	Holistic, food-like	Drug-like, potent
Liver risk	Very low	Moderate (idiosyncratic)

💊 Curcumin: Food or Drug?

Curcumin in piperine-enhanced form behaves pharmacologically like a modern drug, bypassing many of the body’s natural metabolic checkpoints. While this may be ideal for acute inflammation or targeted therapeutic use, it also increases the risk of liver burden, particularly in people with pre-existing liver conditions, genetic variations in CYP450 enzymes, or those on multiple medications.

In essence, when curcumin is taken in isolation and concentrated form, we are no longer dealing with food, but with a powerful bioactive substance—one that needs to be treated with the same caution as pharmaceuticals.

✅ Conclusion: Therapeutic Wisdom from Nature

While high-bioavailability curcumin may have its place in short-term therapy, it is crucial to respect the boundaries of traditional herbal wisdom. Whole turmeric—used with food or in simple teas—offers a safer long-term strategy with a more favorable safety profile.

If choosing a supplement, opt for formulations without piperine, or those that use phospholipid-based delivery systems (like Meriva®) which may offer enhanced absorption without enzyme inhibition.

As modern science continues to validate ancient remedies, it also reminds us: more is not always better—especially when nature has already provided a safe template for healing.

📚 References

Lukefahr, A. L., McGill, M. R., Tandri, H. and Bourgeois, J. A., 2020. Hepatotoxicity associated with curcumin supplementation: A systematic review and meta-analysis. The American Journal of Medicine, 133(11), pp.1388–1393.

Nelson, K. M., Dahlin, J. L., Bisson, J., Graham, J., Pauli, G. F. and Walters, M. A., 2017. The essential medicinal chemistry of curcumin. Journal of Medicinal Chemistry, 60(5), pp.1620–1637.

Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R. and Srinivas, P. S., 1998. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64(4), pp.353–356.

Copyright © 2025 www.zentnutri.blogspot.com. All Rights Reserved.

Endogenous Antioxidants and Aging: Why Glutathione, CoQ10, and ALA Decline—and How to Restore Them

Discover how aging, chronic illness, and stress deplete natural antioxidants—and how holistic strategies can restore balance

By Brian S.

Learn why key antioxidants like glutathione, alpha-lipoic acid, and CoQ10 decline with age. Explore holistic and lifestyle practices to restore antioxidant levels and promote healthy aging.

Why Elder Individuals Lack Key Endogenous Antioxidants: Glutathione, Alpha-Lipoic Acid, and Coenzyme Q10

The human body is equipped with its own antioxidant defense system, producing vital compounds like glutathione, alpha-lipoic acid (ALA), and coenzyme Q10 (CoQ10). These substances neutralize oxidative stress and protect cellular health. However, aging and certain chronic conditions can significantly reduce their levels, leading to increased vulnerability to inflammation, fatigue, and disease.

The Role of Endogenous Antioxidants

Antioxidant	Nature	Primary Functions
Glutathione	Water-soluble	Detoxification, immune support, redox balance
Alpha-Lipoic Acid (ALA)	Water- & lipid-soluble	Regenerates other antioxidants; mitochondrial cofactor
Coenzyme Q10 (CoQ10)	Lipid-soluble	Cellular energy (ATP) production; membrane antioxidant

These antioxidants are synthesized endogenously but require sufficient nutrients and a functioning metabolic system.

Why Levels Decline with Age

1. Inflammaging

"Inflammaging" refers to chronic, low-grade inflammation that arises with aging. This persistent inflammation increases reactive oxygen species (ROS), contributing to the depletion of endogenous antioxidants (Franceschi et al., 2000).

2. Chronic Diseases

• Diabetes increases oxidative stress via glycation end-products and mitochondrial dysfunction (Baynes, 1991).
• Hypertension disrupts redox balance, promoting vascular oxidative stress (Rodrigo et al., 2011).

These conditions deplete glutathione and CoQ10 more rapidly and hinder ALA’s mitochondrial role.

3. Chronic Psychological Stress

Stress elevates cortisol, which has been shown to suppress antioxidant enzyme systems, including glutathione peroxidase (McIntosh et al., 1998).

4. Polypharmacy

Medications such as statins lower CoQ10 synthesis (Gugliucci, 2005), while acetaminophen depletes glutathione reserves. Multiple drugs increase oxidative burden on the liver.

5. Nutrient Deficiencies

Key micronutrients like selenium, B-complex vitamins, magnesium, and amino acids (e.g., cysteine, glycine) are precursors for glutathione and CoQ10 synthesis. Deficiencies impair production (Wu et al., 2004).

Protective Strategies for Healthy Aging

1. Balanced Nutrition

Include a wide variety of vegetables and fruits rich in antioxidants, such as berries, leafy greens, citrus fruits, and cruciferous vegetables. Sulfur-containing foods like garlic and onions also support the body’s production of glutathione.

2. Avoid Toxin Accumulation

Prevent constipation, minimize consumption of deep-fried foods, reduce added sugar intake, and avoid habitual overeating—all of which contribute to oxidative stress and chronic inflammation.

3. Physical Activity

Engage in moderate, regular exercise to enhance the activity of endogenous antioxidant enzymes and support mitochondrial health (Radak et al., 2008).

4. Ample, Quality Sleep

Sufficient restorative sleep promotes mitochondrial repair and boosts melatonin, a potent antioxidant involved in circadian regulation.

5. Stress Management

Practices such as mindfulness, meditation, prayer, and meaningful social connections help reduce chronic cortisol elevation and systemic inflammation.

6. Consult Holistic Health Practitioners

In conjunction with a healthy lifestyle, consulting experienced holistic health and preventive medicine practitioners may provide additional support. They may recommend specific herbal combinations that exhibit antioxidant, anti-inflammatory, detoxifying, cytoprotective, and neuroprotective properties, offering integrative benefits for healthy aging.

Conclusion

Glutathione, alpha-lipoic acid, and CoQ10 are critical endogenous antioxidants that decline with age, especially in the presence of stress, chronic disease, and poor lifestyle habits. However, this decline is not irreversible. Through informed lifestyle practices, nutrient-dense diets, and the guidance of holistic practitioners, individuals can preserve and even restore their antioxidant defenses, promoting longevity and resilience against age-related diseases.

References

Baynes, J. W. (1991). Role of oxidative stress in development of complications in diabetes. Diabetes, 40(4), 405–412.

Franceschi, C., Bonafè, M. & Valensin, S. (2000). Inflamm-aging: an evolutionary perspective on immunosenescence. Annals of the New York Academy of Sciences, 908(1), 244–254.

Gugliucci, A. (2005). Statins, oxidative stress and the endothelium: a new pharmacological tool for cardiovascular disease prevention. Current Drug Targets - Cardiovascular & Hematological Disorders, 5(2), 133–140.

McIntosh, L. J., Hong, K. E., & Sapolsky, R. M. (1998). Glucocorticoids may alter antioxidant enzyme capacity in the brain: baseline studies. Journal of Neurochemistry, 70(1), 208–215.

Radak, Z., Chung, H. Y., & Goto, S. (2008). Systemic adaptation to oxidative challenge induced by regular exercise. Free Radical Biology and Medicine, 44(2), 153–159.

Rodrigo, R., Gonzalez, J., & Paoletto, F. (2011). The role of oxidative stress in the pathophysiology of hypertension. Hypertension Research, 34, 431–440.

Wu, G., Y. Z., Yang, S., Lupton, J. R., & Turner, N. D. (2004). Glutathione metabolism and its implications for health. The Journal of Nutrition, 134(3), 489–492.

Footnote:

While alpha-lipoic acid (ALA) and coenzyme Q10 (CoQ10) are valuable endogenous antioxidants and mitochondrial cofactors, their supplementation may provide minimal benefit in the absence of supportive lifestyle factors. Chronic inflammation, poor diet, oxidative stress, and impaired mitochondrial function reduce the body’s ability to utilize these compounds effectively. ALA, for example, requires the presence of other antioxidants like vitamins C and E to regenerate them (Packer et al., 1997), while CoQ10's role in ATP synthesis depends on intact mitochondrial machinery (Littarru & Tiano, 2007). Moreover, studies suggest that the clinical benefits of these supplements are enhanced when combined with lifestyle modifications such as exercise, antioxidant-rich diets, and stress reduction (Higgins et al., 2020). Without such a foundation—or supportive herbal strategies (e.g., adaptogens, detoxifiers)—the impact of supplementation is likely to be limited.

References:

• Higgins, J.P., Babu, K.M., Deuster, P.A. & Shearer, J. (2020). Coenzyme Q10 supplementation and exercise performance: a systematic review. Journal of Strength and Conditioning Research, 34(2), pp. 470–481.
• Littarru, G.P. & Tiano, L. (2007). Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Molecular Biotechnology, 37(1), pp. 31–37.
• Packer, L., Witt, E.H. & Tritschler, H.J. (1997). Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine, 19(2), pp. 227–250.

Copyright © 2025 www.zentnutri.blogspot.com. All Rights Reserved.

Health Misinformation and Disinformation: How Modern and Alternative Practices Spread It and What You Can Do

Understanding misleading health advice in modern medicine, dietetics, and alternative therapies—and how to protect yourself with science-backed knowledge

By Brian S 

Discover the truth behind health misinformation and disinformation from modern medicine, nutrition, and alternative medicine. Learn how to recognize false claims, why they spread, and how to make informed health decisions based on science.

Health Misinformation and Disinformation: What Are They?

In today’s digital world, health advice spreads fast—but not always accurately. With the rise of social media and wellness influencers, the boundaries between evidence-based medicine, outdated beliefs, and pseudoscience have become increasingly difficult to discern.

Two terms often used in this context are misinformation and disinformation. Though similar, their origins and intentions differ, and understanding these distinctions is crucial to protecting your health and the health of others.

Defining Misinformation and Disinformation

• Misinformation is incorrect or misleading health information shared without intent to deceive. It usually stems from ignorance or misunderstanding.

• Disinformation, on the other hand, is intentionally misleading or false information disseminated for political, ideological, or financial gain (Wardle & Derakhshan, 2017).

Both can cause harm—especially when adopted by the public or spread by trusted figures, including doctors, dietitians, and alternative healers.

How Misinformation and Disinformation Spread in Health Fields

Though we often associate misinformation with social media or fringe practitioners, it exists across the spectrum of healthcare, from hospital corridors to herbal shops. Below, we explore real examples from:

• Modern Medicine
• Modern Dietetics
• Alternative Medicine

1. Modern Medicine: Unintended and Corporate Harm

Misinformation: Antibiotics for Viral Infections

Even today, some physicians prescribe antibiotics for viral illnesses such as the common cold or flu, despite decades of warnings. This contributes to antibiotic resistance, an issue the World Health Organization (2023) calls "one of the biggest threats to global health" ([WHO, 2023]).

Disinformation: Suppressed Drug Trial Data

A glaring example of disinformation was the Vioxx scandal. Merck marketed rofecoxib as a safe anti-inflammatory while withholding internal data showing increased risks of heart attack and stroke (Graham, 2005). It is estimated that over 60,000 people died before the drug was pulled from the market.

“What made this scandal so egregious is that data suppression was deliberate. Profit was prioritized over life.” (Graham, 2005)

2. Modern Dietetics: Misguided Guidelines and Industry Manipulation

Misinformation: The Low-Fat Craze

For decades, health authorities promoted low-fat diets as universally healthy. This led to an increase in sugar and refined carbohydrate intake, correlating with the rise of obesity and Type 2 diabetes (Ludwig et al., 2018). The intention may have been good, but the consequences were tragic.

Disinformation: The Sugar Industry Cover-up

In the 1960s, the sugar industry funded research that minimized sugar’s role in heart disease while blaming saturated fat—a move that shaped decades of dietary policy (Kearns et al., 2016). The deception remained hidden until recently.

“The Sugar Research Foundation paid Harvard scientists to shift the blame from sugar to fat—compromising public health for decades” (Kearns et al., 2016). 

3. Alternative Medicine: Natural Myths and Exploitation

: “Natural Means Safe”

Many believe that herbal remedies and traditional therapies are inherently safe. But natural doesn’t mean risk-free. Herbs like comfrey, kava, and aristolochic acid have been linked to liver damage and cancer, especially when misused or taken with pharmaceuticals (FDA, 2022).

Disinformation: Miracle Cure Scams

Certain figures in the alternative health space promote unproven “miracle cures” for cancer—such as black salve or laetrile (vitamin B17)—with no scientific backing. These often exploit desperate patients, delaying or replacing effective treatment (FTC, 2021).

“Deceptive marketing of natural cancer cures has been an ongoing problem... patients are at real risk of harm” (FTC, 2021).

How to Avoid Falling for False Health Information

1. Be Skeptical of Emotional or Sensational Claims

• “Doctors don’t want you to know…”
• “Secret cure Big Pharma is hiding…”
• “One miracle herb that heals everything…”

These are all red flags of manipulation.

2. Examine the Source

• Does the speaker have medical or scientific credentials?
• Are they quoting peer-reviewed research?
• Are they trying to sell you something?

3. Look for Scientific Consensus

Individual studies may mislead. Look for systematic reviews, meta-analyses, or statements from independent bodies like WHO, Cochrane, or PubMed-indexed journals.

4. Cross-Check with Reputable Databases

Use:

• PubMed
• Cochrane Library
• CDC/WHO websites
• Academic journals

5. Stay Humble—Science Evolves

Knowledge is dynamic. What’s “true” today may be revised tomorrow. Be willing to update your beliefs based on emerging evidence.

Conclusion: Knowledge Is Your Best Defense

In the war against health misinformation and disinformation, the best armor is critical thinking and scientific literacy. By questioning what we hear, checking our sources, and understanding the complexity of health science, we can make better decisions—not just for ourselves, but for our communities.

Whether you're reading a scientific journal, a wellness blog, or a friend’s Facebook post—always ask, verify, and think critically. Health is too important to be left in the hands of half-truths.

References 

• FDA. (2022). Herbs and Safety. U.S. Food & Drug Administration. Available at: https://www.fda.gov
• FTC. (2021). FTC Cracks Down on Bogus Cancer Cures. Federal Trade Commission. Available at: https://www.ftc.gov
• Graham, D. (2005). 'COX-2 inhibitors, other NSAIDs, and cardiovascular risk: the seduction of common sense'. The Lancet, 365(9450), pp. 2021–2022.
• Kearns, C.E., Schmidt, L.A. and Glantz, S.A. (2016). ‘Sugar Industry and Coronary Heart Disease Research: A Historical Analysis of Internal Industry Documents’. JAMA Internal Medicine, 176(11), pp. 1680–1685.
• Ludwig, D.S., Willett, W.C., Volek, J.S. and Neuhouser, M.L. (2018). ‘Dietary fat: From foe to friend?’. Science, 362(6416), pp. 764–770.
• Wardle, C. and Derakhshan, H. (2017). Information Disorder: Toward an interdisciplinary framework. Council of Europe Report.
• WHO. (2023). Antibiotic resistance. World Health Organization. Available at: https://www.who.int

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Was Queen of Sheba’s Influence Present in Borobudur? Uncovering Middle Eastern Roots Behind Ratu Boko and Java’s Sacred History

Reassessing Dr. Anurak Sutham’s Controversial Findings: Ancient Water Engineering, Sun Worship, and the Forgotten Origins of Borobudur’s Builders

By Brian S.

Was Borobudur influenced by Middle Eastern culture before Buddhism’s arrival? Dr. Anurak Sutham’s research proposes that Ratu Boko may carry Queen of Sheba’s legacy—challenging mainstream archaeological views.

Borobudur, the world’s largest Buddhist temple, is commonly recognized as a Mahayana architectural masterpiece from the 8th to 9th centuries, constructed under the Sailendra Dynasty. However, could its historical roots reach further—perhaps to the era of seafaring merchants from Arabia or Persia who once docked in Java?

This bold question was posed by Dr. Anurak Sutham, an archaeologist and cultural anthropologist from Thailand. His controversial hypothesis challenges traditional beliefs about the origins of Borobudur and its neighboring hilltop complex, Ratu Boko.

Interestingly, Dr. Sutham Phongphit and other regional historians have also proposed that Borobudur may have originated from a royal palace or secular residence, or at least served a non-religious function before being transformed into a Buddhist monument.

Who Is Dr. Anurak Sutham?

Dr. Sutham is a former lecturer at Chiang Mai University, specializing in comparative iconography and ancient maritime cultures. Through decades of research across Java, Sumatra, and Southern Thailand, he developed an unconventional thesis: that Ratu Boko predates Borobudur, and its builders may have included immigrants or spiritual envoys from the Middle East, potentially linked to the Queen of Sheba (Bilqis).

Key Discoveries That Challenge the Consensus

1. Ratu Boko’s Precise Water Systems: Echoes of Middle Eastern Engineering

The finely constructed stone reservoirs at Ratu Boko resemble desert hydraulic technologies such as the Sabaean water systems or Persian yakhchāl ice storage domes (Stein, 1998).

2. Winged Bird Reliefs at the Gateway: Simurgh, Not Garuda?

The wide-winged bird carvings at Ratu Boko do not closely resemble the Hindu-Buddhist Garuda, but rather the Simurgh from Persian mythology or guardian birds seen in Sabaean palace art (Gutas, 2004).

3. Solar Orientation and Temple Layout: A Site of Sun Worship?

Several structures at Ratu Boko are aligned east–west, implying solar veneration, akin to the Almaqah Temple in Ma’rib, Yemen (Kitchen, 1994).

4. Clothing Depicted in Reliefs: Parthian Style, Not Indian?

Fragments show figures wearing belted tunics and round turbans, resembling Parthian or Sabaean dress more than local Hindu-Buddhist attire (Yamauchi, 1990).

Was Borobudur Influenced by These Hidden Cultures?

Beyond Middle Eastern influence, some Southeast Asian scholars like Dr. Sutham Phongphit have speculated that Borobudur’s lowest tier—now covered—likely depicted worldly narratives such as daily life and human desires (Karmawibhangga), not just religious symbolism.

This lends weight to the idea that its original structure may have been secular or royal, later repurposed as a Buddhist monument. Furthermore, the megalithic architectural style at Borobudur’s base also points to pre-Buddhist and Hindu-Javanese palace influences, indicating possible reuse of an older palace foundation during the Sailendra period.

The syncretic cultural context of 8th–9th century Java—a fusion of Hindu, Buddhist, and indigenous beliefs—makes such a transition plausible. In fact, some local legends link Borobudur to a lost kingdom, though these accounts are often shrouded in myth.

Why Is This Theory Contested?

Dr. Sutham’s hypothesis challenges Indonesia’s official archaeological narrative, which attributes Borobudur’s origin to local and Indian influences. His theory of Middle Eastern links and connections to the Queen of Sheba is deemed speculative due to the lack of written documentation. Still, the concept of cultural transmission via maritime trade routes remains a relevant academic framework (Miksic, 2007).

Conclusion: Ratu Boko and Borobudur as Historical Palimpsests

Whether or not the Queen of Sheba ever set foot in Java, the structures and symbols at Ratu Boko and Borobudur may represent the cultural footprints of many civilizations meeting through trade and migration. They are palimpsests—layers of history revealing the interweaving of Sabaean, Indian, and Buddhist traditions.

The research of Dr. Anurak Sutham and the perspectives of regional historians like Dr. Sutham Phongphit remind us that history is not always linear. Borobudur is not just a monument of one civilization, but a confluence of memories from many, united by the trade winds of the Indian Ocean.

References 

Gutas, D., 2004. Greek Thought, Arabic Culture: The Graeco-Arabic Translation Movement in Baghdad and Early 'Abbasid Society. London: Routledge.

Kitchen, K.A., 1994. The World of the Old Testament. Grand Rapids: Baker Academic.

Miksic, J.N., 2007. Old Javanese Gold: The Hunter Thompson Collection at the Yale University Art Gallery. New Haven: Yale University Press.

Rahman, R., 2010. Revisiting Ancient Java: Critical Perspectives on Pre-Islamic Southeast Asia. Jakarta: Sejarah Nusantara Foundation.

Stein, M.L., 1998. 'Ancient Hydraulic Technologies in the Middle East.' Journal of Arid Environments, 39(1), pp.15–29.

Sutham, A., 2009. Ratu Boko and the Legacy of Bilqis: An Alternative Archaeological Interpretation. Penang: Maritime Heritage Press.

Yamauchi, E.M., 1990. Persia and the Bible. Grand Rapids: Baker Book House.

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How Sugar Sabotages Herbal Medicine: The Hidden Barrier to Antioxidant Absorption

Exploring How High Sugar Intake Reduces the Effectiveness of Herbs and Antioxidants

By Brian S.

Learn how sugar interferes with the absorption and bioactivity of herbal antioxidants. Discover the science behind this effect and how to optimize herbal therapy by limiting sugar intake.

Visual contrast of antioxidant-rich fruits, turmeric, and herbs on one side, and refined sugar cubes on the other, symbolizing how sugar inhibits antioxidant absorption in the gut

Herbal medicine has long been celebrated for its antioxidant, anti-inflammatory, and restorative properties. However, few realize that a high-sugar diet may directly compromise the effectiveness of these remedies. Modern research now reveals that sugar doesn’t just add calories—it interferes with the very mechanisms that allow herbs to function in the body.

The Overlooked Problem: Sugar and Herbal Absorption

Many herbal antioxidants—like quercetin, catechins, curcumin, and resveratrol—are reliant on specific transporters and metabolic pathways to be absorbed and activated. Yet, refined sugar (glucose, fructose, and sucrose) can inhibit or overload these systems, ultimately reducing the bioavailability of these plant compounds.

1. Transporter Competition: Sugar Blocks Phytochemical Absorption

Plant-based antioxidants like quercetin and green tea catechins use specific transporters in the intestines, such as SGLT1, GLUT2, and OATP1A2. These same transporters also handle glucose. When sugar is present in high amounts, these transporters are saturated, reducing the body's ability to absorb herbs consumed at the same time (Youdim et al., 2003; Cermak et al., 2004).

2. Advanced Glycation End Products (AGEs): Antioxidant Neutralizers

High sugar levels promote non-enzymatic glycation reactions, leading to the formation of advanced glycation end products (AGEs). These AGEs:

• Inactivate dietary antioxidants, preventing them from neutralizing free radicals.
• Inhibit key antioxidant enzymes, such as superoxide dismutase and glutathione peroxidase (Brownlee, 2001).

This means sugar doesn't just compete with herbs—it actively destroys their antioxidant potential.

3. Sugar Increases Oxidative Stress

Ironically, sugar—while suppressing antioxidant absorption—also amplifies oxidative stress. Chronic intake leads to:

• Increased mitochondrial ROS (reactive oxygen species).
• Activation of NADPH oxidase, producing more free radicals (Urakawa et al., 2003).

Herbal antioxidants are often insufficient to balance this pro-oxidant burden when sugar intake remains high.

4. Gut Microbiota Disruption: A Hidden Blockade

The gut microbiome plays a critical role in converting certain polyphenols and tannins into bioactive forms. However, sugar promotes dysbiosis, including overgrowth of Firmicutes and loss of beneficial Bacteroidetes. This alters the metabolism of:

• Ellagitannins from pomegranate and berries (reduced urolithin production).
• Isoflavones and lignans from soy and flax.

This impairs the systemic availability of these plant-derived metabolites (Selma et al., 2009).

5. Inflammatory Signaling: Blocking the Antioxidant Response

A high sugar diet activates inflammatory cascades:

• Increased NF-κB and mTOR signaling.
• Reduced expression of NRF2, the master switch for antioxidant response genes (Kawabata et al., 2010).

Thus, sugar not only blocks antioxidant absorption—it prevents the body from even responding to them properly.

Implications for Herbal Practitioners and Health Enthusiasts

For those relying on herbal medicine for preventive care, detoxification, or chronic disease management, sugar may be a silent saboteur. Consider the following practices:

• Avoid sweetened herbal preparations (e.g., syrup-based tonics, rock sugar).
• Use water or unsweetened tinctures as delivery mediums.
• Encourage low-glycemic diets to complement herbal regimens.
• Educate patients on the antagonistic role of sugar in natural healing.

Conclusion

The relationship between sugar and herbal bioactivity is no longer anecdotal—it's backed by a growing body of biochemical and clinical evidence. To maximize the benefits of herbs and antioxidants, reducing sugar intake is not optional—it’s essential. In the age of functional foods and natural medicine, awareness of this interaction may define the success or failure of a wellness plan.

References 

Brownlee, M., 2001. 'Biochemistry and molecular cell biology of diabetic complications.' Nature, 414(6865), pp.813–820.

Cermak, R., Landgraf, S. and Wolffram, S., 2004. 'Quercetin glucosides inhibit glucose uptake into brush-border-membrane vesicles of porcine jejunum.' British Journal of Nutrition, 91(6), pp.849–855.

Kawabata, K., Mukai, R. and Ishisaka, A., 2010. 'Quercetin and related polyphenols: new insights and implications for their potential health benefits.' Current Opinion in Biotechnology, 21(2), pp.279–281.

Selma, M.V., Espín, J.C. and Tomás-Barberán, F.A., 2009. 'Interaction between phenolics and gut microbiota: role in human health.' Journal of Agricultural and Food Chemistry, 57(15), pp.6485–6501.

Urakawa, H. et al., 2003. 'Oxidative stress is associated with adiposity and insulin resistance in men.' The Journal of Clinical Endocrinology & Metabol'ism, 88(10), pp.4673–4676.

Youdim, K.A. et al., 2003. 'Interaction between flavonoids and the blood-brain barrier: in vitro studies.' NeuroReport, 14(1), pp.39–45.

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Ejaculation Frequency & BPH: Debunking the 21-Times-a-Month Myth with Science

Can Ejaculating More Really Protect Your Prostate? What Research Reveals About BPH Prevention  

By Brian S.

The claim that ejaculating 21 times monthly prevents BPH is widespread. Uncover the truth with evidence-based insights on prostate health, risk factors, and effective prevention strategies.  

A pervasive myth in men’s health suggests ejaculating 21 times a month shields against benign prostatic hyperplasia (BPH). While rooted in prostate cancer research, this claim oversimplifies BPH’s complex causes. Let’s dissect the science and explore proven strategies for prostate health.  

Origins of the 21-Times Myth

The “21 times” idea traces back to a 2004 study linking frequent ejaculation to reduced prostate cancer risk (Leitzmann et al.). Researchers hypothesized that regular ejaculation might flush carcinogens or reduce fluid stagnation. However, **this study focused solely on cancer—not BPH**, a distinct condition with different triggers.  

Understanding BPH: More Than Just a Swollen Gland

BPH, affecting 50% of men over 50, involves non-cancerous prostate growth. Key drivers include:  

- Hormonal shifts: Rising dihydrotestosterone (DHT) with age.  

- Chronic inflammation: Linked to oxidative stress and infections.  

- Metabolic factors: Obesity, insulin resistance, and sedentary lifestyles.  

While ejaculation may ease temporary prostate congestion, it doesn’t target these root causes.  

What Research Says About Ejaculation and BPH 

- No Direct Link: A 2016 review (Rosenberg et al.) found no strong evidence tying ejaculation frequency to reduced BPH risk.  

- Lifestyle Over Frequency: A 2019 Chinese study (Li et al.) noted that diet and exercise outweighed ejaculation in mitigating symptoms.  

Key Takeaway: Ejaculation’s role in BPH prevention remains unproven, unlike its tentative link to prostate cancer.  

Proven Strategies to Reduce BPH Risk

1. Combat Hormonal Imbalances:  

   - Limit DHT via foods (saw palmetto, pumpkin seeds) or medications (finasteride) under medical guidance.  

2. Anti-Inflammatory Diet:  

   - Prioritize tomatoes (lycopene), green tea, and omega-3-rich fish.  

3. Stay Active:  

   - Regular exercise (e.g., brisk walking, strength training) lowers obesity-related risks.  

4. Manage Metabolic Health:  

   - Reduce sugar and refined carbs to prevent insulin resistance.  

When to Seek Help: Recognizing BPH Symptoms

BPH often manifests as:  

- Frequent urination, especially at night.  

- Weak urine stream or difficulty starting.  

- Feeling of incomplete bladder emptying.  

Consult a urologist if symptoms arise—early intervention prevents complications.  

Conclusion

Ejaculating 21 times a month may offer psychological benefits, but robust evidence for BPH prevention is lacking. Prioritize actionable steps: anti-inflammatory diets, hormonal balance, and metabolic health.  Always consult a qualified healthcare provider or holistic health practitioner for personalized guidance.

References 

Leitzmann, M.F. et al., 2004. 'Ejaculation frequency and subsequent risk of prostate cancer.' JAMA, 291(13), pp.1578–1586.  

Rosenberg, M.T. et al., 2016. 'Ejaculatory frequency and the risk of prostate diseases: A review.' Current Urology Reports, 17(11), p.86.  

Li, J. et al.  , 2019. 'Associations of sexual activity with lower urinary tract symptoms and prostate volume in middle-aged and elderly Chinese men.' The Aging Male, 22(2), pp.117–123.  

Key Takeaways

- BPH and prostate cancer have distinct causes; don’t conflate them.  

- Focus on diet, exercise, and metabolic health for prostate wellness.  

- Consult a urologist for persistent urinary symptoms.  

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Bone Health in the Elderly with Degenerative Diseases: Why Calcium Alone Isn't the Answer

Understanding the Real Root Causes of Bone Loss in Alzheimer’s, Parkinson’s, Diabetes, and Arthritis

By Brian S.

Discover why calcium supplements may be harmful for elderly with chronic illnesses like Alzheimer’s, diabetes, and arthritis. Learn anti-inflammatory and antioxidant-rich diet strategies that truly support bone health.

Elderly individuals living with chronic degenerative diseases—such as Alzheimer’s, Parkinson’s, diabetes, arthritis, and hypertension—face not only cognitive and metabolic challenges but also a greatly increased risk of bone loss and fractures. Conventional wisdom promotes calcium supplementation, often bundled with magnesium, vitamin D3, and vitamin K2, as the first line of defense against osteoporosis. However, emerging research suggests this strategy may be ineffective—or even harmful—when inflammaging, mitochondrial dysfunction, and chronic oxidative stress are left unaddressed (Wei et al., 2020; Bolland et al., 2015).

Rethinking Calcium Supplementation in Chronic Illness

While calcium is essential for bone structure, excessive supplementation without addressing inflammation may cause more harm than good. In elderly individuals with chronic conditions, elevated inflammation and disrupted mitochondrial function can lead to calcium mismanagement. This can fuel cellular apoptosis, promote vascular calcification, and increase oxidative stress, rather than improving bone mineral density (Zhao et al., 2019).

Moreover, calcium entering inflamed or senescent cells may disrupt mitochondrial membrane potential, impair ATP production, and trigger pro-apoptotic pathways (Görlach et al., 2015). This paradox highlights the need to look beyond mere mineral intake.

Anti-Inflammatory, Antioxidant-Prioritized Nutrition

Instead of focusing solely on calcium, the priority should be supporting the body's antioxidant defenses and reducing systemic inflammation, which together preserve both bone and mitochondrial health.

Key dietary strategies include:

• Eliminating ultra-processed carbohydrates, which increase advanced glycation end-products (AGEs) and oxidative load
• Emphasizing whole foods with complex carbohydrates like legumes, root vegetables, and whole grains
• Incorporating omega-3-rich fats from sardines, flaxseeds, walnuts, and chia
• Eating a variety of colorful vegetables, especially cruciferous and leafy greens

Top bone-supporting functional foods:

• Leafy greens: High in bioavailable calcium and vitamin K1
• Fermented foods: Like natto and kefir for vitamin K2 and gut health
• Fatty fish: Rich in vitamin D and anti-inflammatory EPA/DHA
• Turmeric, ginger, and berries: Provide potent polyphenols and antioxidants
• Nuts and seeds: Natural sources of magnesium, zinc, and boron

Micronutrients That Truly Matter

Instead of high-dose calcium, elderly individuals with chronic inflammation benefit more from:

• Magnesium (Mg2+) – Cofactor for over 300 enzymes and crucial for vitamin D activation
• Vitamin D3 – Modulates immune function and bone remodeling
• Vitamin K2 (MK-7) – Helps prevent calcium from being deposited in arteries
• Zinc, boron, and silica – Enhance bone matrix integrity
• Polyphenols – Protect mitochondrial DNA and reduce oxidative burden

Food-Based Mineral Strategy: Barley Grass and Organic Molasses

For elderly individuals with degenerative diseases, whole-food sources of critical minerals offer a more synergistic and absorbable option compared to isolated supplements. Two particularly powerful yet underutilized options are barley grass and dried organic molasses crystals.

In terms of specific nutrient contributions, barley grass (about 2 teaspoons) provides approximately 15 to 25 milligrams of magnesium and 150 to 250 milligrams of potassium, along with small amounts of calcium and iron. Dried organic molasses (about 2 teaspoons), on the other hand, offers a richer mineral profile—typically contributing 40 to 60 milligrams of magnesium, 300 to 400 milligrams of potassium, 80 to 120 milligrams of calcium, and 2 to 3 milligrams of iron.

When combined, this pairing can deliver around 55 to 85 milligrams of magnesium, 450 to 650 milligrams of potassium, 90 to 140 milligrams of calcium, and roughly 2.5 to 3.5 milligrams of iron, depending on the source and concentration. These amounts may not match pharmaceutical-grade supplements in potency, but they can significantly contribute to daily requirements in a balanced, bioavailable, and food-based form—especially beneficial for individuals with compromised absorption due to aging or chronic inflammation.

Lifestyle Interventions: Synergy with Nutrition

1. Exercise

Weight-bearing activity like walking, yoga, and resistance bands stimulates osteoblast function and maintains muscle mass—key for preventing falls.

2. Sleep and circadian rhythm

Melatonin supports not only brain function but also bone formation through its antioxidant role (Amstrup et al., 2013).

3. Stress reduction

Chronic cortisol elevation leads to increased bone resorption and calcium excretion.

4. Avoidance of alcohol and smoking

Both have direct toxic effects on osteoblasts and disrupt vitamin D metabolism.

NOTE:

All suggestions made in this blog are also believed to be beneficial for elderly individuals with obesity, post-stroke recovery, and cardiovascular diseases—including atherosclerotic plaque buildup, mitral valve disorders, and related heart conditions. These strategies support systemic anti-inflammatory balance, vascular health, and overall metabolic resilience.

Conclusion: A Holistic Bone Strategy for the Chronically Ill Elderly

Elderly individuals with long-term illnesses should not default to calcium supplementation as a one-size-fits-all solution. Instead, they need a nutrient-rich, anti-inflammatory, and antioxidant-supportive diet paired with lifestyle adjustments that address the root causes of bone degeneration—oxidative stress, mitochondrial dysfunction, and chronic inflammation.

In this way, we can support not only bone health but also overall metabolic, cognitive, and cardiovascular wellness.

References:

Amstrup, A.K., Sikjaer, T., Heickendorff, L., Mosekilde, L. and Rejnmark, L., 2013. 'Melatonin improves bone mineral density at the femoral neck in postmenopausal women with osteopenia: a randomized, double-blind, placebo-controlled trial.' Journal of Pineal Research, 54(3), pp.221–229.

Bolland, M.J., Grey, A., Avenell, A. and Gamble, G.D., 2015. 'Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis.' BMJ, 351, p.h4580.

Görlach, A., Bertram, K., Hudecova, S. and Krizanova, O., 2015. 'Calcium and ROS: A mutual interplay.' Redox Biology, 6, pp.260–271.

Wei, J., Xu, H., Davies, M.R. and Hemmings, G.P., 2020. 'Inflammaging and bone health: the role of chronic inflammation in age-related osteoporosis.' Frontiers in Endocrinology, 11, p.449.

Zhao, J., Xie, Y., Liu, Y., Zhong, J. and Liu, Y., 2019. 'Role of mitochondria in osteogenesis and osteoclastogenesis: Potential therapeutic strategies for osteoporosis.' Free Radical Biology and Medicine, 130, pp.287–299.

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The Calcium Paradox Revisited: Are Supplements Fueling Future Illnesses? :

How Overprescribed Calcium May Trigger a Cascade of Health Issues and Unnecessary Drug Use

By Brian S. 

Is your calcium supplement doing more harm than good? Discover how excess calcium may raise your risk for heart disease, kidney stones, and polypharmacy. Learn natural alternatives for bone health. 

For decades, calcium has been promoted as an essential nutrient for preventing osteoporosis and fractures, particularly in older adults. Doctors often prescribe calcium supplements, assuming them to be harmless. Yet emerging research reveals a hidden paradox: excessive calcium supplementation may be causing the very ailments it aims to prevent — and even more.

This article explores the overlooked consequences of routine calcium prescriptions and how they may inadvertently lead to a cycle of drug dependency and chronic illness.

1. The Medicalization of Calcium: When Prevention Becomes a Problem

Prescribing calcium has become almost reflexive in modern medicine, especially for postmenopausal women and the elderly. However, this approach often ignores the individual’s dietary intake, hormonal balance, renal function, and nutrient co-factors. When supplementation is generalized instead of personalized, unintended health risks emerge.

“Calcium supplements should not be given as a matter of routine but should follow a comprehensive evaluation of dietary intake and clinical need” (Heaney, 2013).

2. The Hidden Dangers of Excessive Calcium Supplementation

a. Cardiovascular Complications

Excess calcium from supplements — especially when not properly absorbed into the bone matrix — can accumulate in blood vessels. This process, known as vascular calcification, increases the risk of atherosclerosis, myocardial infarction, and stroke.

A meta-analysis of randomized controlled trials found that calcium supplementation was associated with a 30% increased risk of heart attack (Bolland et al., 2010). The study raises concern that calcium pills, unlike food-based sources, cause sharp rises in serum calcium, which may damage arterial walls.

b. Kidney Stone Formation

Calcium supplements, particularly calcium carbonate, can raise urinary calcium levels. This increases the risk of calcium oxalate stone formation, especially in dehydrated individuals or those with high oxalate diets.

c. Micronutrient Interference

High calcium intake can impair the absorption of magnesium, zinc, and iron (Rosanoff et al., 2012). These minerals are essential for enzymatic functions, immune health, and mood regulation. Deficiencies may lead to fatigue, anxiety, and immune dysregulation, which may be wrongly treated with additional prescriptions — such as antidepressants or immunosuppressants.

d. Gastrointestinal Distress

Calcium supplements often cause constipation, bloating, or nausea, leading patients to seek over-the-counter laxatives or acid suppressants. These additional medications may introduce their own risks — a cascade of unnecessary drug use.

3. The Prescription Cascade: One Pill Leads to Another

Imagine this scenario:
A 65-year-old woman is given calcium supplements for osteopenia. Months later, she develops fatigue, occasional chest pain, and constipation. Her physician prescribes a beta-blocker, statin, and laxative — without realizing the chain began with calcium overuse.

This phenomenon is known as the prescription cascade — where side effects from one drug lead to another prescription, often without reassessing the root cause.

“The burden of polypharmacy in older adults is exacerbated when preventive measures themselves introduce new risks” (Reid et al., 2016).

4. The Natural Approach: Bone Health without Overreliance on Pills

Instead of reflexively prescribing calcium, a food-first, individualized strategy offers better outcomes:

• Dietary Sources: Sardines, tahini, sesame seeds, collard greens, tofu, and fermented dairy provide absorbable calcium with natural cofactors.
• Synergistic Nutrients: Ensure optimal intake of vitamin D3, vitamin K2, and magnesium to direct calcium into bones and away from arteries.
• Weight-Bearing Exercise: Stimulates osteoblasts and enhances bone mineral density without pills.
• Targeted Testing: Monitor serum calcium, parathyroid hormone (PTH), 25(OH) vitamin D, and renal markers before initiating supplementation.

5. Final Thoughts: Time to Rethink the Calcium Doctrine

Calcium is vital — but context matters. Supplementation without proper assessment may result in cardiovascular harm, metabolic imbalances, and a dependency on future prescriptions. We must embrace a holistic, nutrient-aware approach to bone health that prioritizes diet, movement, and biochemical individuality.

The calcium paradox reminds us that more is not always better, and prevention must never come at the cost of long-term harm.

References

Bolland, M.J., Avenell, A., Baron, J.A., Grey, A., MacLennan, G.S. and Reid, I.R., 2010. 'Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis.' BMJ, 341, p.c3691.

Heaney, R.P., 2013. 'Calcium supplementation and incident cardiovascular events.' Nutrition in Clinical Practice, 28(1), pp.40–45.

Rosanoff, A., Weaver, C.M. and Rude, R.K., 2012. 'Suboptimal magnesium status in the United States: are the health consequences underestimated?.' Nutrition Reviews, 70(3), pp.153–164.

Reid, I.R., Bolland, M.J. and Grey, A., 2016. Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis. Lancet, 383(9912), pp.146–155.

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Why Arthritis Strikes Harder After 40: The Role of Inflammation, Nutrition and Lifestyle

Exploring How Inflammation, Poor Diet, and Aging-Related Changes Weaken Joint Health and Increase Arthritis Risk

Discover why arthritis becomes more common after 40. Learn how chronic inflammation, malnutrition, and sedentary lifestyles impair stem cell repair and accelerate joint degeneration.

By Brian S.

Arthritis, especially osteoarthritis, is often considered a natural part of aging. But why does it tend to manifest more frequently — and more painfully — after the age of 40? While wear and tear is part of the story, emerging research points to chronic low-grade inflammation, malnutrition, and lifestyle factors as primary contributors. These hidden culprits impair the body’s natural ability to regenerate joint tissues, particularly through the suppression of stem cell function and the breakdown of collagen and cartilage proteins.

1. Inflammaging and the Breakdown of Joint Renewal

Aging is accompanied by inflammaging, a slow and silent rise in inflammatory activity throughout the body (Franceschi & Campisi, 2014). This chronic inflammation increases the release of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6, which inhibit the proliferation of mesenchymal stem cells (MSCs) responsible for regenerating joint tissues (Chen et al., 2017). As a result, joints lose their ability to repair damage effectively.

Inflammation also upregulates enzymes such as matrix metalloproteinases (MMPs), which break down essential cartilage and tendon components including collagen, elastin, and proteoglycans (Martel-Pelletier et al., 2008). Over time, cartilage degradation exceeds regeneration, laying the foundation for osteoarthritis.

2. Hidden Sources of Chronic Inflammation

Several lifestyle and metabolic changes that often begin or worsen after the age of 40 further stoke inflammation:

a. Polypharmacy

Many older adults take multiple medications daily, a phenomenon known as polypharmacy. Some drug combinations can disrupt gut microbiota and liver detox pathways, inadvertently contributing to systemic inflammation (Maher et al., 2014).

b. Constipation and Gut Toxin Accumulation

Chronic constipation, common among older adults, allows toxins like lipopolysaccharides (LPS) from gut bacteria to be reabsorbed into the bloodstream, triggering immune responses and promoting inflammation (Vitetta et al., 2013).

c. Nutritional Imbalances and Malnourishment

Malnutrition — particularly micronutrient deficiency — is surprisingly common in the elderly, especially those with reduced appetite or who eat monotonous diets (Volkert et al., 2019). Diets low in antioxidants, vitamin C, vitamin D, and omega-3 fatty acids increase susceptibility to inflammation and cartilage damage.

d. Lack of Antioxidant-Rich Foods

Antioxidants play a vital role in neutralizing reactive oxygen species (ROS), which accumulate with age and worsen joint inflammation. A diet low in fruits, vegetables, herbs, and polyphenol-rich foods reduces the body’s ability to cope with oxidative stress, weakening joint integrity (Henrotin et al., 2019).

e. Physical Inactivity

Movement is medicine. Regular exercise stimulates synovial fluid production, improves nutrient delivery to cartilage, and reduces inflammation by lowering systemic cytokine levels (Lange et al., 2020). Yet many adults over 40 become more sedentary, accelerating joint stiffness and degeneration.

3. Aging Stem Cells and Joint Degeneration

The stem cells responsible for regenerating joint components also age and become senescent, losing their regenerative potential. Worse still, senescent cells secrete harmful molecules known as senescence-associated secretory phenotypes (SASP), which include inflammatory cytokines and proteases (Coppe et al., 2010). This not only reduces joint repair but actively damages surrounding tissue.

Conclusion: A Multifactorial Degeneration Process

Arthritis after 40 is not merely about aging joints — it’s about the intersection of inflammation, malnutrition, and inactivity. Prevention and management require a holistic approach, including:

• Anti-inflammatory nutrition
• Regular physical activity
• Gut health optimization
• Minimizing unnecessary medications
• Promoting antioxidant-rich foods

Supporting the body’s natural repair mechanisms — especially its stem cells — is key to maintaining joint health and preventing or slowing arthritis progression.

References

Chen, Q., Shou, P., Zhang, L., Xu, C., Zheng, C., Han, Y., Li, W., Huang, Y., Zhang, X., Yin, Y., Wang, Y. and Shi, Y., 2017. 'An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells.' Stem Cells, 32(2), pp.327-337.

Coppe, J.P., Desprez, P.Y., Krtolica, A. and Campisi, J., 2010. 'The senescence-associated secretory phenotype: the dark side of tumor suppression.' Annual Review of Pathology: Mechanisms of Disease, 5, pp.99-118.

Franceschi, C. and Campisi, J., 2014. 'Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.' The Journals of Gerontology: Series A, 69(Suppl 1), pp.S4-S9.

Henrotin, Y., Lambert, C., Couchourel, D., Ripoll, C. and Chiotelli, E., 2019. 'Nutraceuticals: do they represent a new era in the management of osteoarthritis?–a narrative review from the lessons taken with five products'. Osteoarthritis and Cartilage, 19(1), pp.1-21.

Lange, K.H., Andersen, J.L., Beyer, N., Isaksson, F., Larsson, B., Rasmussen, M.H., Juul, A. and Kjaer, M., 2020. 'Impact of physical training on muscle strength and musculoskeletal pain in patients with chronic diseases: a randomized controlled trial.' Scandinavian Journal of Medicine & Science in Sports, 30(3), pp.509-521.

Maher, R.L., Hanlon, J. and Hajjar, E.R., 2014. 'Clinical consequences of polypharmacy in elderly.' Expert Opinion on Drug Safety, 13(1), pp.57-65.

Martel‐Pelletier, J., Boileau, C., Pelletier, J.P. and Roughley, P.J., 2008. 'Cartilage in normal and osteoarthritis conditions.' Best Practice & Research Clinical Rheumatology, 22(2), pp.351-384.

Vitetta, L., Coulson, S., Linnane, A.W. and Butt, H., 2013. 'The gastrointestinal microbiome and musculoskeletal diseases: a beneficial role for probiotics and prebiotics.' Pathogens, 2(4), pp.606-626.

Volkert, D., Beck, A.M., Cederholm, T., Cruz‐Jentoft, A., Goisser, S., Hooper, L., Kiesswetter, E., Norman, K., Schneider, S.M. and Sieber, C.C., 2019. 'ESPEN guideline on clinical nutrition and hydration in geriatrics.' Clinical Nutrition, 38(1), 

Footnote:

While this article focuses on general arthritis and osteoarthritis, it’s worth noting that rheumatoid arthritis (RA) also shares similar inflammatory triggers, such as gut dysbiosis, oxidative stress, and micronutrient deficiencies. However, RA is autoimmune in nature, involving the immune system mistakenly attacking joint linings. Notably, hormonal fluctuations—especially the drop in estrogen during perimenopause and menopause—have been implicated in RA flare-ups and higher prevalence in older women. Estrogen has anti-inflammatory properties, and its deficiency may disrupt immune tolerance and promote the activation of T cells and autoantibody production, exacerbating joint inflammation in RA (Cutolo et al., 2012; Hughes et al., 2014).

References

Cutolo, M., Capellino, S., Montagna, P., Ghiorzo, P., Sulli, A. and Villaggio, B., 2012. 'Sex hormone modulation of cell growth and apoptosis of the human monocytic/macrophage cell line.' Arthritis Research & Therapy, 14(3), p.R149.

Hughes, G.C., 2014. 'Progesterone and autoimmune disease.' Autoimmunity Reviews, 11(6-7), pp.A502–A514.

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Gastric and Intestinal Ulcers: Is Bloating Really Caused by Constipation?

Unpacking the Truth Behind Belching, Gas, and "Wind" in Ulcer Sufferers

Is constipation the main cause of gas and bloating in ulcer patients? Discover the real reasons behind “wind” in gastric and intestinal ulcers, including inflammation, spasms, and low food intake.

By Brian S., MH, MD (Alt. Med.) | Zent Nutri

Have you ever heard someone say that the belching or “wind” experienced by people with gastric or intestinal ulcers is simply due to constipation? It’s not uncommon to hear this in holistic circles. In fact, I recently came across a response from a holistic practitioner who insisted that flatulence and bloating in ulcer sufferers are mainly a result of constipation.

But here's where things got interesting—when asked about a case where the patient vomits every time they try to eat, consuming very little food, the practitioner had no reply. No constipation, yet still gas and discomfort? Let's dig deeper into the science and physiology behind this.

The Physiology Behind Ulcers and Gas

1. Inflammation Comes First

Ulcers—whether in the stomach (gastric ulcers) or intestines (intestinal ulcers)—are open sores caused by erosion of the mucosal lining. These sores often result from H. pylori infection, excessive NSAID use, or stress, and are typically accompanied by inflammation (Sung et al., 2009).

Inflammation activates local immune cells and releases substances like histamine, prostaglandins, and cytokines. These mediators trigger local pain receptors, increase gastric acid secretion, and may disrupt smooth muscle function (Wallace, 2008).

2. Spasms and Nerve Irritation

The gastrointestinal tract has its own nervous system, the enteric nervous system, which coordinates muscle movement. Inflammation irritates these nerves, leading to smooth muscle spasms. These spasms can cause cramping, pain, and erratic movement of gas and digestive contents (Furness, 2012).

3. Gas Accumulation: Belching and Flatulence

In the stomach, ulcers and inflammation can make the digestive tract hypersensitive. This can cause the person to swallow more air (aerophagia) due to anxiety, nausea, or irregular eating patterns. The trapped air is expelled as belching, sometimes with an acidic or sour aftertaste due to reflux (Katz et al., 2013).

In the intestines, spasms and slowed motility can lead to fermentation of undigested food by gut bacteria, even in the absence of a large food intake. This fermentation releases gases like hydrogen, methane, and carbon dioxide, leading to bloating and flatulence (Camilleri, 2020).

What If There's No Food Intake or Constipation?

Here lies the crux: even when a person barely eats due to vomiting—common in severe gastric ulcers or gastroparesis—gas and "wind" can still occur. This is not due to constipation but to spasms, fermentation, and altered gut motility. The bloating may even worsen due to empty stomach acidity and delayed gastric emptying.

Constipation’s Role: Not the Sole Cause

Constipation certainly can contribute to bloating, but it is not the main reason for gas in ulcer sufferers. It becomes problematic when we overemphasize it and ignore the more relevant issues like:

• Chronic inflammation

• Gastric hypersensitivity

• Acid imbalance

• Nerve irritation

• Dysbiosis or small intestinal bacterial overgrowth (SIBO)

A Balanced Holistic Approach

As holistic health professionals, it's vital we stay grounded in physiology and pathophysiology. Instead of reducing all symptoms to constipation, we must consider:

• Mucosal healing: using slippery elm, marshmallow root, or deglycyrrhizinated licorice (DGL)

• Spasm relief: using peppermint (in reflux-free cases), chamomile and fennel

• Inflammation control: with turmeric or aloe vera

• Microbiome support: probiotics or fermented foods (when tolerated)

• Stress management: as psychological stress worsens gastric output and motility disorders

Conclusion

So, is gas in ulcer patients just a result of constipation? Not quite. Inflammation, nerve irritation, and disordered motility are far more relevant in most cases—especially when food intake is low or vomiting occurs. Let’s not oversimplify the complex workings of the gut. A nuanced understanding makes us better healers.

References

Camilleri, M. (2020) ‘Bloating and abdominal distension: pathophysiology and management’, Nature Reviews Gastroenterology & Hepatology, 17(11), pp. 731–740.

Furness, J.B. (2012) ‘The enteric nervous system and neurogastroenterology’, Nature Reviews Gastroenterology & Hepatology, 9(5), pp. 286–294.

Katz, P.O., Gerson, L.B. and Vela, M.F. (2013) ‘Guidelines for the diagnosis and management of gastroesophageal reflux disease’, The American Journal of Gastroenterology, 108(3), pp. 308–328.

Sung, J.J.Y. et al. (2009) ‘Systematic review: the global incidence and prevalence of peptic ulcer disease’, Alimentary Pharmacology & Therapeutics, 29(9), pp. 938–946.

Wallace, J.L. (2008) ‘Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?’, Physiological Reviews, 88(4), pp. 1547–1565.

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